Association of PTPN22 polymorphsims and ankylosing spondylitis susceptibility.

BACKGROUND As a susceptibility gene for AS, the polymorphsims of PTPN22 associated with disease susceptibility. METHODS We selected two SNPs of rs1217406 and rs1217414 within PTPN22 with Haploview software and investigated the relationship between the SNPs of PTPN22 gene and AS susceptibility. 120 AS patients and 100 healthy people were enrolled from Qilu Hospital of Shandong University. And we genotyped the SNPs of PTPN22 with PCR-RFLP method. RESULTS The results showed that C allele (rs1217406) and T allele (rs1217414) both were risk factors for AS (OR: 3.12, 2.13). The persons with A-T, C-C or C-T haplotypes were more likely to suffer AS (OR: 3.17, 3.66, 4.011). CONCLUSIONS Due to the close relationship of PTPN22 and AS, the study may be helpful for the early diagnosis and differential diagnosis.